:root{--max-width:1100px;--border-radius:12px;--font-mono:ui-monospace,Menlo,Monaco,"Cascadia Mono","Segoe UI Mono","Roboto Mono","Oxygen Mono","Ubuntu Monospace","Source Code Pro","Fira Mono","Droid Sans Mono","Courier New",monospace;--foreground-rgb:0,0,0;--background-start-rgb:214,219,220;--background-end-rgb:255,255,255;--primary-glow:conic-gradient(from 180deg at 50% 50%,#16abff33 0deg,#0885ff33 55deg,#54d6ff33 120deg,#0071ff33 160deg,transparent 360deg);--secondary-glow:radial-gradient(#fff,hsla(0,0%,100%,0));--tile-start-rgb:239,245,249;--tile-end-rgb:228,232,233;--tile-border:conic-gradient(#00000080,#00000040,#00000030,#00000020,#00000010,#00000010,#00000080);--callout-rgb:238,240,241;--callout-border-rgb:172,175,176;--card-rgb:180,185,188;--card-border-rgb:131,134,135}@media (prefers-color-scheme:dark){:root{--foreground-rgb:255,255,255;--background-start-rgb:0,0,0;--background-end-rgb:0,0,0;--primary-glow:radial-gradient(rgba(1,65,255,.4),rgba(1,65,255,0));--secondary-glow:linear-gradient(to bottom right,rgba(1,65,255,0),rgba(1,65,255,0),rgba(1,65,255,.3));--tile-start-rgb:2,13,46;--tile-end-rgb:2,5,19;--tile-border:conic-gradient(#ffffff80,#ffffff40,#ffffff30,#ffffff20,#ffffff10,#ffffff10,#ffffff80);--callout-rgb:20,20,20;--callout-border-rgb:108,108,108;--card-rgb:100,100,100;--card-border-rgb:200,200,200}}*{box-sizing:border-box}html{height:auto;min-height:100%}body,html{-webkit-font-smoothing:antialiased}#onetrust-banner-sdk.otFlat{max-height:unset!important}.margin-auto{margin:auto 0}@media (prefers-color-scheme:dark){html{color-scheme:dark}}.IndicationsAndSafety__block__titleBlock__heroTitle,.heading-h3{font-family:proxima-bold,sans-serif;font-weight:700;font-size:2.4rem;line-height:26px;letter-spacing:0}@media(max-width:767px){.IndicationsAndSafety__block__titleBlock__heroTitle,.heading-h3{font-size:2rem;line-height:24px}}.IndicationsAndSafety__descBlock h5,.IndicationsAndSafety__expandssi__wrapper .expandsafety h5,.IndicationsAndSafety__wrapper .expandsafety h5,.heading-h5{font-family:proxima-bold,sans-serif;font-weight:700;font-size:1.8rem;line-height:22px;letter-spacing:0}.margin-top-45{margin-top:44px}@media(max-width:991px){.margin-top-45{margin-top:32px}}@media(max-width:767px){.margin-top-45{margin-top:56px}}.IndicationsAndSafety{position:fixed;bottom:-10px;left:50%;width:100%;transition:transform .3s ease-in-out,opacity .3s ease-in-out;z-index:99999}@media(max-width:991px){.IndicationsAndSafety{z-index:99999}}.IndicationsAndSafety--collapsed{z-index:0}.IndicationsAndSafety--collapsed .IndicationsAndSafety__expandssi__wrapper,.IndicationsAndSafety--collapsed .IndicationsAndSafety__wrapper{transform:translateY(100%);opacity:0}.IndicationsAndSafety__expandssi__wrapper,.IndicationsAndSafety__wrapper{background-color:#fff;transition:all .2s ease-in-out;border-top-left-radius:15px;border-top-right-radius:15px;border-left:1px solid #bebebe;border-right:1px solid #bebebe}@media(max-width:991px){.IndicationsAndSafety__expandssi__wrapper,.IndicationsAndSafety__wrapper{margin:auto}.IndicationsAndSafety__expandssi__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock__heroTitle,.IndicationsAndSafety__expandssi__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock__heroTitle,.IndicationsAndSafety__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock__heroTitle,.IndicationsAndSafety__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock__heroTitle{font-size:20px}}.IndicationsAndSafety__expandssi__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__expandssi__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock .icons{position:absolute;right:5px;top:5px}@media(min-width:768px){.IndicationsAndSafety__expandssi__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__expandssi__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__wrapper .firstContentHeading .IndicationsAndSafety__block__titleBlock .icons,.IndicationsAndSafety__wrapper .lastContentHeading .IndicationsAndSafety__block__titleBlock .icons{right:14px;top:10px}}.IndicationsAndSafety__expandssi__wrapper .cursor-pointer,.IndicationsAndSafety__wrapper .cursor-pointer{background-color:#fff;border-radius:15px 15px 0 0;position:relative}.IndicationsAndSafety__wrapper.collapsed .cursor-pointer,.collapsed.IndicationsAndSafety__expandssi__wrapper .cursor-pointer{border-radius:15px 15px 0 0}.IndicationsAndSafety__wrapper.collapsed .cursor-pointer .IndicationsAndSafety__block,.collapsed.IndicationsAndSafety__expandssi__wrapper .cursor-pointer .IndicationsAndSafety__block{transition:all .2s ease-in-out}.IndicationsAndSafety__expandssi__wrapper .expandsafety,.IndicationsAndSafety__wrapper .expandsafety{font-size:18px;line-height:22px;font-weight:100;color:#707070}.IndicationsAndSafety__expandssi__wrapper .expandsafety .misc-footnote,.IndicationsAndSafety__wrapper .expandsafety .misc-footnote{font-size:1.5rem;line-height:18px}.IndicationsAndSafety__expandssi__wrapper .expandsafety h5,.IndicationsAndSafety__wrapper .expandsafety h5{margin-bottom:10px;color:#444;font-family:proxima-bold,sans-serif}.IndicationsAndSafety__expandssi__wrapper .expandsafety .expanded-isi__safety .highlighted,.IndicationsAndSafety__wrapper .expandsafety .expanded-isi__safety .highlighted{color:#6cc04a}.IndicationsAndSafety__expandssi__wrapper .expandsafety .leftrightspace .base-ul,.IndicationsAndSafety__wrapper .expandsafety .leftrightspace .base-ul{margin-bottom:10px}.IndicationsAndSafety__expandssi__wrapper .expandsafety .leftrightspace .base-ul>li:before,.IndicationsAndSafety__wrapper .expandsafety .leftrightspace .base-ul>li:before{top:9px}@media(max-width:991px){.IndicationsAndSafety__expandssi__wrapper .expandsafety .leftrightspace,.IndicationsAndSafety__wrapper .expandsafety .leftrightspace{padding:0!important;margin-right:5px}}.IndicationsAndSafety__block{padding:20px 20px 15px;display:flex;justify-content:center;align-items:center;border:1px solid #bebebe;border-bottom:0;border-radius:15px 15px 0 0;overflow:hidden;cursor:pointer}@media(max-width:991px){.IndicationsAndSafety__block{padding:15px 21px 10px}}.IndicationsAndSafety__block:last-child{border-bottom:0}.IndicationsAndSafety__block__titleBlock{display:flex;justify-content:space-between;align-items:center;border:none;background:transparent;width:100%;text-align:left}@media(max-width:767px){.IndicationsAndSafety__block__titleBlock{gap:12px}}.IndicationsAndSafety__block__titleBlock__heroTitle{font-size:24px;line-height:22px;color:#444}@media(max-width:767px){.IndicationsAndSafety__block__titleBlock__heroTitle{width:90%}}.IndicationsAndSafety__descBlock{margin-bottom:10px;font-size:18px;line-height:30px;padding-left:21px;padding-right:28px;color:#707070;overflow:hidden}.IndicationsAndSafety__descBlock h5{font-family:proxima-bold,sans-serif;color:#444;margin-bottom:10px}.IndicationsAndSafety__descBlock .safety-information__content .highlighted{color:#6cc04a}.IndicationsAndSafety__descBlock.firstContent p,.IndicationsAndSafety__descBlock.lastContent p{margin:0;font-size:14px;line-height:20px}.IndicationsAndSafety__descBlock.firstContent p span,.IndicationsAndSafety__descBlock.lastContent p span{font-size:14px;line-height:20px}.IndicationsAndSafety__descBlock.firstContent p,.IndicationsAndSafety__descBlock.lastContent p{margin:0!important;padding:0!important}@media(max-width:991px){.IndicationsAndSafety__descBlock{padding-left:21px;padding-right:21px}}.IndicationsAndSafety__descBlock .base-ul li{margin-bottom:10px!important}.IndicationsAndSafety__descBlock ul{line-height:20px;margin-bottom:10px}.IndicationsAndSafety__descBlock ul li{margin-bottom:0;line-height:20px}.IndicationsAndSafety__expandssi{transition:transform .3s ease;transform:translateY(120%);position:fixed;top:33px;bottom:0;width:100%;max-width:1032px;z-index:190}.IndicationsAndSafety__expandssi--expand{transform:translateY(5%);top:52px;z-index:999999}.IndicationsAndSafety__expandssi__header{padding:21px 23px 16px}@media(min-width:992px){.IndicationsAndSafety__expandssi__header{padding:10px 15px 2px 23px}}.IndicationsAndSafety__expandssi__wrapper{border-bottom-left-radius:15px;border-bottom-right-radius:15px;box-shadow:0 -4px 6px rgba(0,0,0,.1)}@media(max-width:991px){.IndicationsAndSafety__expandssi__wrapper{width:100%;position:relative;border-top-left-radius:15px;border-top-right-radius:15px;border-left:none;border-right:none;margin:auto}}@media(max-width:767px){.IndicationsAndSafety__expandssi__wrapper .IndicationsAndSafety__block__titleBlock .icons{position:absolute;right:0;top:0}}.IndicationsAndSafety__expandssi .d-inline-none{display:none}.IndicationsAndSafety__expandssi .d-expand-block{display:block}.indicationScroll{margin:0 10px 0 24px;padding-bottom:30px;height:72vh;overflow-x:hidden;overflow-y:auto}@media(max-width:991px){.indicationScroll{height:58vh}}@media(min-width:992px){.indicationScroll{margin:0 10px 0 24px}}.indicationScroll--customScrollbar::-webkit-scrollbar{width:10px}.indicationScroll--customScrollbar::-webkit-scrollbar-thumb{background-color:#7f7f7f;border-radius:5px;position:relative;height:100px}.indicationScroll--customScrollbar::-webkit-scrollbar-track{background-color:#fff;border-radius:5px}.spacer-14--b{margin-bottom:14px}.slideUp{transform:translateX(-50%) translateY(0);opacity:1}.slideDown{transform:translateX(-50%) translateY(120%);opacity:0}.overlay{position:fixed;top:0;right:0;bottom:0;left:0;display:block;margin:0;background:rgba(74,74,74,.6) 0 0 no-repeat padding-box;z-index:99999}.expanded-isi__safety .tab-paragraph--ita{color:#7f7f7f;padding-bottom:6px;font-size:18px}.expanded-isi__safety .ssi-footer{color:#707070!important;margin-bottom:0!important}@media(max-width:991px){.expanded-isi__safety .ssi-footer{margin-bottom:10px}}.expanded-isi__safety .ssi-footer a{color:#6fbf4a}@media(max-width:991px){.IndicationsAndSafety__block__titleBlock{text-align:left}.IndicationsAndSafety__expandssi--expand{transform:translateY(0);top:33px;z-index:999999}}@media(max-width:991px)and (max-width:991px){.IndicationsAndSafety__expandssi--expand{top:115px}}@media(min-width:768px){.KeytrudaLenvima .IndicationsAndSafety__descBlock{padding:0}}.KeytrudaLenvima .IndicationsAndSafety__block{padding:15px 12px 0;align-items:flex-start;justify-content:flex-end}@media(min-width:992px){.KeytrudaLenvima .IndicationsAndSafety__block{padding:19px 0 0 13px}}.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock{width:-moz-fit-content;width:fit-content;align-items:flex-start;position:relative}@media(min-width:768px){.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock{position:absolute;top:2px}}.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock .icons{right:-10px!important;top:-12px!important}@media(min-width:768px){.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock .icons{right:-10px!important;top:0!important}}@media(min-width:992px){.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock .icons{right:0!important;top:0!important}}.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock__heroTitle{padding-bottom:16px;line-height:22px;font-size:24px!important;width:100%}@media(min-width:992px){.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock__heroTitle{padding-right:20px;font-size:22px!important;text-align:left}}@media(max-width:767px){.KeytrudaLenvima .IndicationsAndSafety__block__titleBlock__heroTitle{width:92%}}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety h5,.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety p,.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety ul{color:#4a4a4a}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .misc-footnote{padding-left:10px}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .footnote-margin{margin-top:0!important;margin-bottom:10px!important}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .border-right h5{padding-right:10px}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .border-right .remove-spacing,.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .right-isi .remove-spacing{padding-left:0!important}.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .border-right .contentHeight,.KeytrudaLenvima .IndicationsAndSafety__expandssi__wrapper .expandsafety .right-isi .contentHeight{padding-left:5px}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header{padding:17px 20px 0 13px}@media(min-width:992px){.KeytrudaLenvima .IndicationsAndSafety__expandssi__header{padding:17px 20px 0 19px}}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-green:before{display:none}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-green h4{position:relative}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-green h4:before{position:absolute;content:"";width:6px;height:calc(100% - 16px);background-color:#6fbf4a;border-radius:0;left:-10px;top:3px}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-purple:before{display:none}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-purple h4{position:relative}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .base-ul-keytrudalenvima-purple h4:before{position:absolute;content:"";width:6px;height:calc(100% - 16px);background-color:#870051;border-radius:0;left:-10px;top:0}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .IndicationsAndSafety__block__titleBlock{width:100%;position:relative;padding-left:4px!important}.KeytrudaLenvima .IndicationsAndSafety__expandssi__header .IndicationsAndSafety__block__titleBlock .icons{position:absolute;right:-14px!important;top:-15px!important}.KeytrudaLenvima .safety-information__content{width:100%}.KeytrudaLenvima .safety-information__content h5,.KeytrudaLenvima .safety-information__content p,.KeytrudaLenvima .safety-information__content ul{color:#4a4a4a}@media(min-width:768px){.KeytrudaLenvima .safety-information__content .expanded-isi__safety .heading-padding{padding-left:5px}}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .footnote-padding{padding-left:10px}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .misc-footnote{margin:40px 0 30px;padding-left:10px}@media(max-width:767px){.KeytrudaLenvima .safety-information__content .expanded-isi__safety .misc-footnote{margin:16px 0}}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .ssi-footer{padding-left:10px}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-green:before{display:none}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-green h4{position:relative;padding-left:5px}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-green h4:before{position:absolute;content:"";width:6px;height:calc(100% - 16px);background-color:#6fbf4a;border-radius:0;left:-10px;top:4px}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-purple:before{display:none}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-purple h4{position:relative;padding-left:5px}.KeytrudaLenvima .safety-information__content .expanded-isi__safety .base-ul-keytrudalenvima-purple h4:before{position:absolute;content:"";width:6px;height:calc(100% - 16px);background-color:#870051;border-radius:0;left:-10px;top:4px}.KeytrudaLenvima .safety-information__content--column{width:33%}@media(max-width:991px){.KeytrudaLenvima .safety-information__content--column{width:100%}}.KeytrudaLenvima .safety-information__content .base-ul>li{padding:0 10px}.KeytrudaLenvima .safety-information__content .base-ul>li:before{left:0}.KeytrudaLenvima .border-right{border-right:2px solid #bebebe}.KeytrudaLenvima .indicationScroll{margin:0 10px 0 17px}@media(min-width:992px){.KeytrudaLenvima .indicationScroll{margin:0 10px 0 23px}}.icons{background-repeat:no-repeat;background-position:50%;background-size:cover;display:block;width:42px;height:42px}.icons.blue-plus{background-image:url(/images/icons/plus.svg)}.icons.blue-cancel{background-image:url(/images/icons/close.svg)}.icons.blue-right-arrow{background-image:url(/images/icons/keytruda-indication-btn.svg);height:30px;width:30px}.icons.green-right-arrow{background-image:url(/images/icons/keytrudalenvima-indication-btn.svg);height:30px;width:30px}@font-face{font-family:proxima-light;src:url(/_next/static/media/ProximaNova-Light.030a6b43.otf);font-style:normal;font-weight:300}@font-face{font-family:proxima-regular;src:url(/_next/static/media/ProximaNova-Regular.02a14b2f.otf);font-style:normal;font-weight:400}@font-face{font-family:proxima-italics;src:url(/_next/static/media/ProximaNova-Regular.02a14b2f.otf);font-style:italic;font-weight:400}@font-face{font-family:proxima-medium;src:url(/_next/static/media/ProximaNova-Medium.91f0c51f.otf);font-style:normal;font-weight:500}@font-face{font-family:proxima-semi-bold;src:url(/_next/static/media/ProximaNova-Semibold.7ebc4cbf.otf);font-style:normal;font-weight:600}@font-face{font-family:proxima-semi-bold-italic;src:url(/_next/static/media/ProximaNova-Semibold.7ebc4cbf.otf);font-style:italic;font-weight:600}@font-face{font-family:proxima-bold;src:url(/_next/static/media/ProximaNova-Bold.f7af2fb5.otf);font-style:normal;font-weight:700}@font-face{font-family:proxima-bold-italic;src:url(/_next/static/media/ProximaNova-Bold.f7af2fb5.otf);font-style:italic;font-weight:700}@font-face{font-family:proxima-extra-bold;src:url(/_next/static/media/ProximaNova-Extrabold.eba529e9.otf);font-style:normal;font-weight:800}@font-face{font-family:proxima-extra-bold-italic;src:url(/_next/static/media/ProximaNova-Extrabold.eba529e9.otf);font-style:italic;font-weight:800}@font-face{font-family:proxima-black;src:url(/_next/static/media/ProximaNova-Black.0c3fb2df.otf);font-style:normal;font-weight:900}@font-face{font-family:proxima-black-italic;src:url(/_next/static/media/ProximaNova-Black.0c3fb2df.otf);font-style:italic;font-weight:900}@font-face{font-family:invention-regular;src:url(/_next/static/media/Invention-Regular.9c655628.ttf);font-style:normal;font-weight:400}@font-face{font-family:invention-bold;src:url(/_next/static/media/Invention-Bold.49399eb2.ttf);font-style:normal;font-weight:600}@font-face{font-family:Arial-regular;src:local("Arial"),local("ArialMT");font-weight:400;font-style:normal}@font-face{font-family:Arial-italic;src:local("Arial Italic"),local("Arial-ItalicMT");font-weight:400;font-style:italic}@font-face{font-family:Arial-bold;src:local("Arial Bold"),local("Arial-BoldMT");font-weight:700;font-style:normal}@font-face{font-family:Arial-bold-italic;src:local("Arial Bold Italic"),local("Arial-BoldItalicMT");font-weight:700;font-style:italic}@font-face{font-family:Arial-black;src:local("Arial Black"),local("Arial-Black");font-weight:900;font-style:normal}@font-face{font-family:Arial-black-italic;src:local("Arial Black Italic"),local("Arial-BlackItalicMT");font-weight:900;font-style:italic}@font-face{font-family:ArialMTPro-Regular;src:local("ArialMTPro-Regular"),local("ArialMTPro-Regular");font-weight:400;font-style:normal}@font-face{font-family:MinionPro-Regular;src:local("MinionPro-Regular"),local("MinionPro-Regular");font-weight:400;font-style:normal}@font-face{font-family:ArialMTPro-Bold;src:local("ArialMTPro-Bold"),local("ArialMTPro-Bold");font-weight:700;font-style:normal}*{margin:0;padding:0}html{font-size:10px;scroll-padding:60px;color:#444}html.menu-open{overflow:hidden}body{background:#fff;color:#444;font-family:proxima-light,sans-serif;line-height:20px;font-size:1.6rem;overflow-x:hidden;-webkit-font-smoothing:antialiased;display:flex;justify-content:center}body .width-fixed{max-width:1032px;width:100%}a{color:#444;text-decoration:none}h1,h2,h3,h4,h5,p{margin:0}button{background-color:transparent}b,strong{font-family:proxima-bold,sans-serif;font-weight:700}.body-paragraph,.body-paragraph--bld,.body-paragraph--ita,.body-paragraph--sm{font-family:Arial-regular,sans-serif;line-height:24px;font-size:1.6rem;letter-spacing:0}.body-paragraph--ita{font-family:Arial-italic,sans-serif}.body-paragraph--bld{font-family:Arial-bold,sans-serif}.body-paragraph--sm{font-size:1.4rem;line-height:22px}.body-paragraph-links-reg,.body-paragraph-links-reg--bld,.body-paragraph-links-reg--ita,.body-paragraph-links-reg--sm{font-family:Arial-regular,sans-serif;line-height:24px;font-size:1.6rem;letter-spacing:0}.body-paragraph-links-reg--ita{font-family:Arial-italic,sans-serif}.body-paragraph-links-reg--bld{font-family:Arial-bold,sans-serif}.body-paragraph-links-reg--bld,.body-paragraph-links-reg--sm{font-size:1.4rem;line-height:22px}.heading-h1{font-family:proxima-regular,sans-serif;font-weight:400;font-size:6.7rem;line-height:63px;text-transform:uppercase}@media(max-width:767px){.heading-h1{font-size:4.6rem;line-height:43px}}.textWrap{white-space:nowrap}.heading-h2{font-family:proxima-bold,sans-serif;font-weight:800;font-size:3rem;line-height:34px;letter-spacing:0}@media(max-width:767px){.heading-h2{font-size:2.4rem;line-height:28px}}.heading-h3{font-family:proxima-bold,sans-serif;font-weight:700;font-size:2.4rem;line-height:26px;letter-spacing:0}@media(max-width:767px){.heading-h3{font-size:2rem;line-height:24px}}.heading-h4{font-family:proxima-bold,sans-serif;font-weight:800;font-size:2rem;line-height:24px;letter-spacing:0}@media(max-width:767px){.heading-h4{font-size:1.8rem;line-height:22px}}.heading-h5{font-family:proxima-bold,sans-serif;font-weight:700;font-size:1.8rem;line-height:22px;letter-spacing:0}.heading-h5--underline{text-decoration:underline}[class^=heading-] .highlighted{color:#6cc04a}.heading-h6{font-family:proxima-bold,sans-serif;font-weight:700;font-size:1.6rem;line-height:22px;letter-spacing:0}.tab-paragraph,.tab-paragraph--bld,.tab-paragraph--ita{font-family:proxima-regular,sans-serif;line-height:20px;font-size:1.6rem;letter-spacing:0}.tab-paragraph--ita{font-family:proxima-light,sans-serif;font-style:italic}.tab-paragraph--bld{font-family:proxima-bold,sans-serif}.misc-footnote{font-family:proxima-light,sans-serif;font-size:1.3rem;line-height:18px;position:relative}.misc-footnote sup{position:absolute;top:6px;left:-5px}.misc-footnote sup.extraSpace{left:-7px}@media(max-width:480px){.misc-footnote{max-width:344px;width:100%;margin:auto}}[class^=heading-] .highlighted{color:#6fbf4a}.grey-dark-color{color:#444}.green-text-color{color:#6cc04a}.purple-text-color{color:#870051}.pink-text-color{color:#e623df}.blue-text-color{color:#006ead}.blue-text-color--underline{text-decoration:underline}.gray-neutral{color:#707070!important}.text-transform-unset{text-transform:unset!important}.font-weight-semi-bold{font-weight:600}.font-weight-bold{font-weight:700}.font-italic{font-style:italic}.w-8{width:80%}.fs-16{font-size:16px}.fs-18{font-size:18px}.lh-20{line-height:20px}.lh-22{line-height:22px}.base-ul{padding-left:0}.base-ul>li{padding:0 12px;list-style:none;position:relative;margin-bottom:8px}.base-ul>li:last-child{margin-bottom:10px}.base-ul>li:before{position:absolute;content:"";width:4px;height:4px;border-radius:50%;left:4px;top:8px}.base-ul--keytruda>li:before{background-color:#6fbf4a}.base-ul--lenvima>li:before{background-color:#870051}.base-ul ul{padding-left:40px;margin:0}@media(min-width:992px){.base-ul ul{padding-left:40px}}.base-ul ul>li{list-style:none;position:relative}.base-ul ul>li:last-child{margin-bottom:0}.base-ul ul>li:before{position:absolute;content:"-";width:8px;height:0;color:#707070;border-radius:0;left:-10px;top:0;font-size:15px;font-weight:700}.base-ul ul ul{padding-left:50px;margin:0}.base-ul ul ul>li{list-style:none;position:relative;margin-bottom:8px}.base-ul ul ul>li:last-child{margin-bottom:0}.base-ul ul ul>li:before{position:absolute;content:"-";width:6px;height:0;color:#707070;border-radius:0;left:-15px;top:0;font-size:15px;font-weight:700}.base-ul-keytrudalenvima-green{padding-left:10px;position:relative}.base-ul-keytrudalenvima-green:before{position:absolute;content:"";width:6px;height:77px;background-color:#6fbf4a;border-radius:0;left:-5px;top:4px}@media(max-width:767px){.base-ul-keytrudalenvima-green:before{top:5px;height:calc(100% - 22px)}}.base-ul-keytrudalenvima-purple{padding-left:10px;position:relative}.base-ul-keytrudalenvima-purple:before{position:absolute;content:"";width:6px;height:77px;background-color:#870051;border-radius:0;left:-5px;top:4px}@media(max-width:767px){.base-ul-keytrudalenvima-purple:before{top:5px;height:calc(100% - 22px)}}.highlighted-text--keytruda{color:#6cc04a!important}.highlighted-text--lenvima{color:#870051!important}.gap--32{gap:32px}.gap--24{gap:24px}.gap--16{gap:16px}@media(max-width:991px){.gap--16__mob{gap:16px}}.gap--8{gap:8px}.spacer-80{margin:80px}.spacer-80--t{margin-top:80px}.spacer-80--b{margin-bottom:80px}.spacer-80--l{margin-left:80px}.spacer-80--r,.spacer-80--x{margin-right:80px}.spacer-80--x{margin-left:80px}.spacer-80--y{margin-top:80px;margin-bottom:80px}@media(max-width:767px){.spacer-80__mob{margin:80px!important}.spacer-80__mob--t{margin-top:80px!important}.spacer-80__mob--b{margin-bottom:80px!important}.spacer-80__mob--l{margin-left:80px!important}.spacer-80__mob--r,.spacer-80__mob--x{margin-right:80px!important}.spacer-80__mob--x{margin-left:80px!important}.spacer-80__mob--y{margin-top:80px!important;margin-bottom:80px!important}}.spacer-64{margin:64px}.spacer-64--t{margin-top:64px}.spacer-64--b{margin-bottom:64px}.spacer-64--l{margin-left:64px}.spacer-64--r,.spacer-64--x{margin-right:64px}.spacer-64--x{margin-left:64px}.spacer-64--y{margin-top:64px;margin-bottom:64px}@media(max-width:767px){.spacer-64__mob{margin:64px!important}.spacer-64__mob--t{margin-top:64px!important}.spacer-64__mob--b{margin-bottom:64px!important}.spacer-64__mob--l{margin-left:64px!important}.spacer-64__mob--r,.spacer-64__mob--x{margin-right:64px!important}.spacer-64__mob--x{margin-left:64px!important}.spacer-64__mob--y{margin-top:64px!important;margin-bottom:64px!important}}.spacer-52{margin:52px}.spacer-52--t{margin-top:52px}.spacer-52--b{margin-bottom:52px}.spacer-52--l{margin-left:52px}.spacer-52--r,.spacer-52--x{margin-right:52px}.spacer-52--x{margin-left:52px}.spacer-52--y{margin-top:52px;margin-bottom:52px}@media(max-width:767px){.spacer-52__mob{margin:52px!important}.spacer-52__mob--t{margin-top:52px!important}.spacer-52__mob--b{margin-bottom:52px!important}.spacer-52__mob--l{margin-left:52px!important}.spacer-52__mob--r,.spacer-52__mob--x{margin-right:52px!important}.spacer-52__mob--x{margin-left:52px!important}.spacer-52__mob--y{margin-top:52px!important;margin-bottom:52px!important}}.spacer-48{margin:48px}.spacer-48--t{margin-top:48px}.spacer-48--b{margin-bottom:48px}.spacer-48--l{margin-left:48px}.spacer-48--r,.spacer-48--x{margin-right:48px}.spacer-48--x{margin-left:48px}.spacer-48--y{margin-top:48px;margin-bottom:48px}@media(max-width:767px){.spacer-48__mob{margin:48px!important}.spacer-48__mob--t{margin-top:48px!important}.spacer-48__mob--b{margin-bottom:48px!important}.spacer-48__mob--l{margin-left:48px!important}.spacer-48__mob--r,.spacer-48__mob--x{margin-right:48px!important}.spacer-48__mob--x{margin-left:48px!important}.spacer-48__mob--y{margin-top:48px!important;margin-bottom:48px!important}}.spacer-32{margin:32px}.spacer-32--t{margin-top:32px}.spacer-32--b{margin-bottom:32px}.spacer-32--l{margin-left:32px}.spacer-32--r,.spacer-32--x{margin-right:32px}.spacer-32--x{margin-left:32px}.spacer-32--y{margin-top:32px;margin-bottom:32px}@media(max-width:767px){.spacer-32__mob{margin:32px!important}.spacer-32__mob--t{margin-top:32px!important}.spacer-32__mob--b{margin-bottom:32px!important}.spacer-32__mob--l{margin-left:32px!important}.spacer-32__mob--r,.spacer-32__mob--x{margin-right:32px!important}.spacer-32__mob--x{margin-left:32px!important}.spacer-32__mob--y{margin-top:32px!important;margin-bottom:32px!important}}.spacer-24{margin:24px}.spacer-24--t{margin-top:24px}.spacer-24--b{margin-bottom:24px}.spacer-24--l{margin-left:24px}.spacer-24--r,.spacer-24--x{margin-right:24px}.spacer-24--x{margin-left:24px}.spacer-24--y{margin-top:24px;margin-bottom:24px}@media(max-width:767px){.spacer-24__mob{margin:24px!important}.spacer-24__mob--t{margin-top:24px!important}.spacer-24__mob--b{margin-bottom:24px!important}.spacer-24__mob--l{margin-left:24px!important}.spacer-24__mob--r,.spacer-24__mob--x{margin-right:24px!important}.spacer-24__mob--x{margin-left:24px!important}.spacer-24__mob--y{margin-top:24px!important;margin-bottom:24px!important}}.spacer-16{margin:16px}.spacer-16--t{margin-top:16px}.spacer-16--b{margin-bottom:16px}.spacer-16--l{margin-left:16px}.spacer-16--r,.spacer-16--x{margin-right:16px}.spacer-16--x{margin-left:16px}.spacer-16--y{margin-top:16px;margin-bottom:16px}@media(max-width:767px){.spacer-16__mob{margin:16px!important}.spacer-16__mob--t{margin-top:16px!important}.spacer-16__mob--b{margin-bottom:16px!important}.spacer-16__mob--l{margin-left:16px!important}.spacer-16__mob--r,.spacer-16__mob--x{margin-right:16px!important}.spacer-16__mob--x{margin-left:16px!important}.spacer-16__mob--y{margin-top:16px!important;margin-bottom:16px!important}}.spacer-10{margin:10px}.spacer-10--t{margin-top:10px}.spacer-10--b{margin-bottom:10px}.spacer-10--l{margin-left:10px}.spacer-10--r,.spacer-10--x{margin-right:10px}.spacer-10--x{margin-left:10px}.spacer-10--y{margin-top:10px;margin-bottom:10px}@media(max-width:767px){.spacer-10__mob{margin:10px!important}.spacer-10__mob--t{margin-top:10px!important}.spacer-10__mob--b{margin-bottom:10px!important}.spacer-10__mob--l{margin-left:10px!important}.spacer-10__mob--r,.spacer-10__mob--x{margin-right:10px!important}.spacer-10__mob--x{margin-left:10px!important}.spacer-10__mob--y{margin-top:10px!important;margin-bottom:10px!important}}.spacer-8{margin:8px}.spacer-8--t{margin-top:8px}.spacer-8--b{margin-bottom:8px}.spacer-8--l{margin-left:8px}.spacer-8--r,.spacer-8--x{margin-right:8px}.spacer-8--x{margin-left:8px}.spacer-8--y{margin-top:8px;margin-bottom:8px}@media(max-width:767px){.spacer-8__mob{margin:8px!important}.spacer-8__mob--t{margin-top:8px!important}.spacer-8__mob--b{margin-bottom:8px!important}.spacer-8__mob--l{margin-left:8px!important}.spacer-8__mob--r,.spacer-8__mob--x{margin-right:8px!important}.spacer-8__mob--x{margin-left:8px!important}.spacer-8__mob--y{margin-top:8px!important;margin-bottom:8px!important}}.spacer-0{margin:0}.spacer-0--t{margin-top:0}.spacer-0--b{margin-bottom:0}.spacer-0--l{margin-left:0}.spacer-0--r,.spacer-0--x{margin-right:0}.spacer-0--x{margin-left:0}.spacer-0--y{margin-top:0;margin-bottom:0}@media(max-width:767px){.spacer-0__mob{margin:0!important}.spacer-0__mob--t{margin-top:0!important}.spacer-0__mob--b{margin-bottom:0!important}.spacer-0__mob--l{margin-left:0!important}.spacer-0__mob--r,.spacer-0__mob--x{margin-right:0!important}.spacer-0__mob--x{margin-left:0!important}.spacer-0__mob--y{margin-top:0!important;margin-bottom:0!important}}.padding-spacer-80{padding:80px}.padding-spacer-80--t{padding-top:80px}.padding-spacer-80--b{padding-bottom:80px}.padding-spacer-80--l{padding-left:80px}.padding-spacer-80--r{padding-right:80px}.padding-spacer-80--x{padding-left:80px;padding-right:80px}.padding-spacer-80--y{padding-top:80px;padding-bottom:80px}@media(max-width:767px){.padding-spacer-80__mob{padding:80px!important}.padding-spacer-80__mob--t{padding-top:80px!important}.padding-spacer-80__mob--b{padding-bottom:80px!important}.padding-spacer-80__mob--l{padding-left:80px!important}.padding-spacer-80__mob--r,.padding-spacer-80__mob--x{padding-right:80px!important}.padding-spacer-80__mob--x{padding-left:80px!important}.padding-spacer-80__mob--y{padding-top:80px!important;padding-bottom:80px!important}}.padding-spacer-48{padding:48px}.padding-spacer-48--t{padding-top:48px}.padding-spacer-48--b{padding-bottom:48px}.padding-spacer-48--l{padding-left:48px}.padding-spacer-48--r{padding-right:48px}.padding-spacer-48--x{padding-left:48px;padding-right:48px}.padding-spacer-48--y{padding-top:48px;padding-bottom:48px}@media(max-width:767px){.padding-spacer-48__mob{padding:48px!important}.padding-spacer-48__mob--t{padding-top:48px!important}.padding-spacer-48__mob--b{padding-bottom:48px!important}.padding-spacer-48__mob--l{padding-left:48px!important}.padding-spacer-48__mob--r,.padding-spacer-48__mob--x{padding-right:48px!important}.padding-spacer-48__mob--x{padding-left:48px!important}.padding-spacer-48__mob--y{padding-top:48px!important;padding-bottom:48px!important}}.padding-spacer-32{padding:32px}.padding-spacer-32--t{padding-top:32px}.padding-spacer-32--b{padding-bottom:32px}.padding-spacer-32--l{padding-left:32px}.padding-spacer-32--r{padding-right:32px}.padding-spacer-32--x{padding-left:32px;padding-right:32px}.padding-spacer-32--y{padding-top:32px;padding-bottom:32px}@media(max-width:767px){.padding-spacer-32__mob{padding:32px!important}.padding-spacer-32__mob--t{padding-top:32px!important}.padding-spacer-32__mob--b{padding-bottom:32px!important}.padding-spacer-32__mob--l{padding-left:32px!important}.padding-spacer-32__mob--r,.padding-spacer-32__mob--x{padding-right:32px!important}.padding-spacer-32__mob--x{padding-left:32px!important}.padding-spacer-32__mob--y{padding-top:32px!important;padding-bottom:32px!important}}.padding-spacer-24{padding:24px}.padding-spacer-24--t{padding-top:24px}.padding-spacer-24--b{padding-bottom:24px}.padding-spacer-24--l{padding-left:24px}.padding-spacer-24--r{padding-right:24px}.padding-spacer-24--x{padding-left:24px;padding-right:24px}.padding-spacer-24--y{padding-top:24px;padding-bottom:24px}@media(max-width:767px){.padding-spacer-24__mob{padding:24px!important}.padding-spacer-24__mob--t{padding-top:24px!important}.padding-spacer-24__mob--b{padding-bottom:24px!important}.padding-spacer-24__mob--l{padding-left:24px!important}.padding-spacer-24__mob--r,.padding-spacer-24__mob--x{padding-right:24px!important}.padding-spacer-24__mob--x{padding-left:24px!important}.padding-spacer-24__mob--y{padding-top:24px!important;padding-bottom:24px!important}}.padding-spacer-16{padding:16px}.padding-spacer-16--t{padding-top:16px}.padding-spacer-16--b{padding-bottom:16px}.padding-spacer-16--l{padding-left:16px}.padding-spacer-16--r{padding-right:16px}.padding-spacer-16--x{padding-left:16px;padding-right:16px}.padding-spacer-16--y{padding-top:16px;padding-bottom:16px}@media(max-width:767px){.padding-spacer-16__mob{padding:16px!important}.padding-spacer-16__mob--t{padding-top:16px!important}.padding-spacer-16__mob--b{padding-bottom:16px!important}.padding-spacer-16__mob--l{padding-left:16px!important}.padding-spacer-16__mob--r,.padding-spacer-16__mob--x{padding-right:16px!important}.padding-spacer-16__mob--x{padding-left:16px!important}.padding-spacer-16__mob--y{padding-top:16px!important;padding-bottom:16px!important}}.padding-spacer-10{padding:10px}.padding-spacer-10--t{padding-top:10px}.padding-spacer-10--b{padding-bottom:10px}.padding-spacer-10--l{padding-left:10px}.padding-spacer-10--r{padding-right:10px}.padding-spacer-10--x{padding-left:10px;padding-right:10px}.padding-spacer-10--y{padding-top:10px;padding-bottom:10px}@media(max-width:767px){.padding-spacer-10__mob{padding:10px!important}.padding-spacer-10__mob--t{padding-top:10px!important}.padding-spacer-10__mob--b{padding-bottom:10px!important}.padding-spacer-10__mob--l{padding-left:10px!important}.padding-spacer-10__mob--r,.padding-spacer-10__mob--x{padding-right:10px!important}.padding-spacer-10__mob--x{padding-left:10px!important}.padding-spacer-10__mob--y{padding-top:10px!important;padding-bottom:10px!important}}.padding-spacer-8{padding:8px}.padding-spacer-8--t{padding-top:8px}.padding-spacer-8--b{padding-bottom:8px}.padding-spacer-8--l{padding-left:8px}.padding-spacer-8--r{padding-right:8px}.padding-spacer-8--x{padding-left:8px;padding-right:8px}.padding-spacer-8--y{padding-top:8px;padding-bottom:8px}@media(max-width:767px){.padding-spacer-8__mob{padding:8px!important}.padding-spacer-8__mob--t{padding-top:8px!important}.padding-spacer-8__mob--b{padding-bottom:8px!important}.padding-spacer-8__mob--l{padding-left:8px!important}.padding-spacer-8__mob--r,.padding-spacer-8__mob--x{padding-right:8px!important}.padding-spacer-8__mob--x{padding-left:8px!important}.padding-spacer-8__mob--y{padding-top:8px!important;padding-bottom:8px!important}}.padding-spacer-0{padding:0}.padding-spacer-0--t{padding-top:0}.padding-spacer-0--b{padding-bottom:0}.padding-spacer-0--l{padding-left:0}.padding-spacer-0--r{padding-right:0}.padding-spacer-0--x{padding-left:0;padding-right:0}.padding-spacer-0--y{padding-top:0;padding-bottom:0}@media(max-width:767px){.padding-spacer-0__mob{padding:0!important}.padding-spacer-0__mob--t{padding-top:0!important}.padding-spacer-0__mob--b{padding-bottom:0!important}.padding-spacer-0__mob--l{padding-left:0!important}.padding-spacer-0__mob--r{padding-right:0!important}.padding-spacer-0__mob--x{padding-left:0!important;padding-right:0!important}.padding-spacer-0__mob--y{padding-top:0!important;padding-bottom:0!important}}.cursor-pointer{cursor:pointer}.desktop-only{display:block}@media(max-width:991px){.desktop-only{display:none}}.mobile-only{display:none}@media(max-width:991px){.mobile-only{display:block}}.mobile-container{padding:0 41px}.base-ol li::marker{font-family:proxima-bold,sans-serif}.fda-btn{font-family:proxima-semi-bold,sans-serif}.container,.container-lg,.container-md{--bs-gutter-x:1.6rem}@media(min-width:1200px){.container,.container-lg,.container-md{max-width:960px}}@media(max-width:991px){.container,.container-lg,.container-md{padding:0 30px!important}}.row{margin-right:calc(var(--bs-gutter-x)*-.5);margin-left:calc(var(--bs-gutter-x)*-.5)}.row,[class^=col]{--bs-gutter-x:1.6rem}img{width:100%}.container-fluid{--bs-gutter-x:1.6rem}.ContentLink{color:#006ead;text-decoration:underline}